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Limitations of multiday IV antibiotics
Benefits of 1-dose oritavancin§
High rates of hospitalization6,7
42% of patients admitted solely to receive IV antibiotics, putting patients at risk of nosocomial infections*†
Decrease admissions1,12,13
Prescribe in any convenient outpatient setting:
Prolonged, costly hospital stays2,8-10‡
Vancomycin: 7-10 days8 Daptomycin: 7-14 days9 Inpatient cost per day: ~$2,0002,10
Elevated readmission risk11
~12% national 30-day readmission rate related to skin infections
Reduce readmissions1,3-5
Consistently low infection-related 30-day readmission rates of 0%-3.6%¶ Learn more |
Due to their nature, retrospective studies can contain material limitations and their results should be considered in light of the entire body of available evidence, including clinical trial data. This work was funded by Melinta Therapeutics.
*In a prospective study of 619 patients presenting with serious skin infections.6
†In a 2015 survey of 199 hospitals.7
‡Average length of stay is 5 days.10
§Studies conducted with patients receiving ORBACTIV.
||Results from a real-world, retrospective, descriptive cohort study of 199 patients.2
¶Results from 4 distinct retrospective studies comprised of a combined 611 patients.1,3-5
The efficacy of KIMYRSA® has been established from adequate and well-controlled trials of another oritavancin product, ORBACTIV®, in patients with ABSSSI.
Study design: Admitted patients who received either oritavancin (n=99) to expedite discharge or were discharged on oral step-down antibiotics (n=100).2
Study design: Admitted patients who received either oritavancin (n=99) to expedite discharge or were discharged on oral step-down antibiotics (n=100).2
Study design: This pilot evaluated the use of oritavancin in the ED or observation unit as a measure to avert hospital inpatient admissions between January 2017 and December 2017. The primary outcome was LOS, defined as the total time in hours from presentation to the ED until discharge home, including time spent in the observation or inpatient unit.13
Study design: This pilot evaluated the use of oritavancin in the ED or observation unit as a measure to avert hospital inpatient admissions between January 2017 and December 2017. The primary outcome was LOS, defined as the total time in hours from presentation to the ED until discharge home, including time spent in the observation or inpatient unit.13
ABSSSI, acute bacterial skin and skin structure infection; ED, emergency department; IV, intravenous; LOS, length of stay; MRSA, methicillin-resistant Staphylococcus aureus; SSTI, skin and soft tissue infections; SoC, standard of care.
References: 1. Redell M, Moeck G, Lucasti C, et al. A real-world patient registry for oritavancin demonstrates efficacy and safety consistent with the phase 3 SOLO program. Open Forum Infect Dis. 2018;5(6):ofy051. doi:10.1093/ofid/ofy051 2. Whittaker C, Lodise TP, Nhan E, Reilly J. Expediting discharge in hospitalized, adult patients with skin and soft tissue infections who received empiric vancomycin therapy with oritavancin: description of findings from an institutional pathway. Drugs Real World Outcomes. 2020;7(suppl 1):30-35. doi:10.1007/s40801-020-00196-6 3. Anastasio PJ, Wolthoff P, Galli A, Fan W. Single-dose oritavancin compared to standard of care IV antibiotics for acute bacterial skin and skin structure infection in the outpatient setting: a retrospective real-world study. Infect Dis Ther. 2017;6(1):115-128. doi:10.1007/s40121-016-0145-7 4. Turner E, Estrada S, Galli A, Armstrong S, Delaportas D. Treatment of acute bacterial skin and skin structure infections (ABSSSI) in the outpatient setting: clinical and economic outcomes from a real-world multi-center study of oritavancin. Poster presented at: ASHP Conference for Pharmacy Leaders; October 17-18, 2016; Chicago, IL. 5. Estrada S, Lodise TP, Tillotson GS, et al. The real world economic and clinical management of adult patients with skin and soft tissue infections (SSTIs) with oritavancin: data from two multicenter observational cohort studies. Drugs Real World Outcomes. 2020;7(suppl 1):6-12. doi:10.1007/s40801-020-00199-3 6. Talan DA, Salhi BA, Moran GJ, et al. Factors associated with decision to hospitalize emergency department patients with skin and soft tissue infection. West J Emerg Med. 2015;16(1):89-97. doi:10.5811/westjem.2014.11.24133 7. Magill SS, O’Leary E, Janelle DL, et al. Changes in prevalence of health care-associated infections in U.S. hospitals. N Engl J Med. 2018;379:1732-44. doi:10.1056/NEJMoa1801550 8. Corey G, Arhin F, Wikler MA, et al. Pooled analysis of single-dose oritavancin in the treatment of acute bacterial skin and skin-structure infections caused by gram-positive pathogens, including a large patient subset with methicillin-resistant Staphylococcus aureus. Int J Antimicrob Agents. 2016;48(5):528-534. doi:10.1016/j.ijantimicag.2016.07.019 9. Daptomycin. Package insert. Merck Sharp & Dohme LLC; 2022. 10. Saddler K, Zhang J, Sul J, et al. Improved economic and clinical outcomes with oritavancin versus a comparator group for treatment of acute bacterial skin and skin structure infections in a community hospital. PLoS One. 2021;16(3):e0248129. doi:10.1371/journal.pone.0248129 11. Bookstaver PB, Jenkins TC, Stenehjem E, et al. Impact of outpatient vs inpatient ABSSSI treatment on outcomes: a retrospective observational analysis of medical charts across US emergency departments. Open Forum Infect Dis. 2018;5(7):ofy109. doi:10.1093/ofid/ofy109 12. Lodise T, Redell M, Armstrong S, Sulham K, Corey G. Efficacy and safety of oritavancin relative to vancomycin for patients with acute bacterial skin and skin structure infections (ABSSSI) in the outpatient setting: results from the SOLO clinical trials. Open Forum Infect Dis. 2017;4(1):ofw274. doi:10.1093/ofid/ofw274 13. Helton B, MacWhinnie A, Minor SB, et al. Early directed oritavancin therapy in the emergency department may lead to hospital avoidance compared to standard treatment for acute bacterial skin and skin structure infections: a real-world retrospective analysis. Drugs Real World Outcomes. 2020;7(suppl 1):20-29. doi:10.1007/ s40801-020-00201-y 14. Williams B, Muklewicz J, Steuber T, Williams A, Edwards J. Comparison of inpatient standard-of-care to outpatient oritavancin therapy for patients with acute uncomplicated cellulitis. J Pharm Pract. 2023;36(1):27-32. doi:10.1177/08971900211021258
Please see Full Prescribing Information for ORBACTIV®.
Please see Full Prescribing Information for KIMYRSA®.
Both KIMYRSA® and ORBACTIV® are oritavancin products that are indicated for the treatment of adult patients with acute bacterial skin and skin structure infections (ABSSSI) caused or suspected to be
ContraindicationsUse of intravenous unfractionated heparin sodium is contraindicated for 120 hours (5 days) after oritavancin